tert-butyl 3-allyl-3-hydroxyazetidine-1-carboxylate synthesis
- Product Name:tert-butyl 3-allyl-3-hydroxyazetidine-1-carboxylate
- CAS Number:1401728-89-9
- Molecular formula:C11H19NO3
- Molecular Weight:213.27
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Yield:1401728-89-9 95%
Reaction Conditions:
with ammonium chloride;zinc in tetrahydrofuran at 10 - 20;
Steps:
1 Synthesis of tert-butyl 3-allyl-3-hydroxyazetidine-1-carboxylate
Add 76 grams of zinc powder to 1L of saturated ammonium chloride solution, add 100 grams of compound 1 in 500 mL of tetrahydrofuran solution and 142 grams of allyl bromide in 300 mL of tetrahydrofuran solution to the reaction solution in turn at 10 °C. , The reaction solution was stirred overnight at 20 °C.The reaction solution was filtered, the filter cake was washed with 500 mL of tetrahydrofuran, and the aqueous phase was extracted four times with 500 mL of ethyl acetate.The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to obtain 119 g of oily compound 2 with a yield of 95%.
References:
CN111533752,2020,A Location in patent:Paragraph 0006
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