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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)-

1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)- synthesis

4synthesis methods
87691-27-8 Synthesis
N-Boc-cis-4-Hydroxy-L-proline

87691-27-8
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1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)-

1404559-22-3
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 19 h / 20 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 6 h / 20 °C / Cooling with ice
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
4.1: 2,6-dimethylpyridine; trifluoromethanesulfonic acid anhydride / dichloromethane / 0.5 h / Cooling with ice
4.2: 21 h / 20 °C

References:

Yoshida, Tomohiro;Akahoshi, Fumihiko;Sakashita, Hiroshi;Kitajima, Hiroshi;Nakamura, Mitsuharu;Sonda, Shuji;Takeuchi, Masahiro;Tanaka, Yoshihito;Ueda, Naoko;Sekiguchi, Sumie;Ishige, Takayuki;Shima, Kyoko;Nabeno, Mika;Abe, Yuji;Anabuki, Jun;Soejima, Aki;Yoshida, Kumiko;Takashina, Yoko;Ishii, Shinichi;Kiuchi, Satoko;Fukuda, Sayaka;Tsutsumiuchi, Reiko;Kosaka, Keigo;Murozono, Takahiro;Nakamaru, Yoshinobu;Utsumi, Hiroyuki;Masutomi, Naoya;Kishida, Hiroyuki;Miyaguchi, Ikuko;Hayashi, Yoshiharu [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 19,p. 5705 - 5719]

1,2-pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) ester, (2S,4S)-

401564-17-8
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1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)-

1404559-22-3
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References
1-Pyrrolidinecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4S)-

401564-35-0
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1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)-

1404559-22-3
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References
401566-77-6 Synthesis
1-Piperazinecarboxylic acid, 4-(1,3-dioxobutyl)-, 1,1-diMethylethyl ester

401566-77-6
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1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)-

1404559-22-3
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References

1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)- Related Search:

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