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1415968-73-8

4-Chloro-3-methyl-benzo[b]thiophene-2-carboxylic acid methyl ester synthesis

1synthesis methods
2365-48-2 Synthesis
Methyl thioglycolate

2365-48-2
348 suppliers
$15.00/25g

87327-69-3 Synthesis
2'-CHLORO-6'-FLUOROACETOPHENONE

87327-69-3
127 suppliers
$8.00/1g

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Yield: 1.67 g

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene at 0 - 20; for 18 h;Inert atmosphere;

References:

Friberg, Anders;Vigil, Dominico;Zhao, Bin;Daniels, R. Nathan;Burke, Jason P.;Garcia-Barrantes, Pedro M.;Camper, Demarco;Chauder, Brian A.;Lee, Taekyu;Olejniczak, Edward T.;Fesik, Stephen W. [Journal of Medicinal Chemistry,2013,vol. 56,# 1,p. 15 - 30] Location in patent:supporting information