tert-Butyl 4-((2-(ethoxycarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate synthesis

2synthesis methods

Product Name:tert-Butyl 4-((2-(ethoxycarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate
CAS Number:1416051-61-0
Molecular formula:C21H27NO5S
Molecular Weight:405.51

ethyl 3-hydroxybenzo[b]thiophene-2-carboxylate

5556-20-7
31 suppliers
$45.00/10mg

109384-19-2 Synthesis

109384-19-2
470 suppliers
$5.00/1g

tert-Butyl 4-((2-(ethoxycarbonyl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

1416051-61-0
4 suppliers
inquiry

Yield:1416051-61-0 97%

Reaction Conditions:

Stage #1: ethyl 3-hydroxybenzothiophene-2-carboxylate;t-butyl 4-hydroxy piperidine-1-carboxylatewith triphenylphosphine in tetrahydrofuran; for 0.333333 h;Inert atmosphere;Mitsunobu Displacement;
Stage #2: with di-isopropyl azodicarboxylate in tetrahydrofuran at 0 - 20; for 1.58333 h;Inert atmosphere;

References:

Rackham, Mark D.;Brannigan, James A.;Moss, David K.;Yu, Zhiyong;Wilkinson, Anthony J.;Holder, Anthony A.;Tate, Edward W.;Leatherbarrow, Robin J. [Journal of Medicinal Chemistry,2013,vol. 56,# 1,p. 371 - 375] Location in patent:supporting information

4892-02-8
143 suppliers
$23.00/1g

1416051-61-0
4 suppliers
inquiry

References