1-?bromo-?4-?(4-?chlorophenoxy)?-?2-?(trifluoromethyl)?- Benzene synthesis

Yield:1417782-30-9 87.99%

Reaction Conditions:

Stage #1: 4-chloro-phenolwith potassium hydroxide in 1-methyl-pyrrolidin-2-one at 120; for 1 h;Inert atmosphere;
Stage #2: 1-bromo-4-fluoro-2-(trifluoromethyl)benzene in 1-methyl-pyrrolidin-2-one at 140; for 5 h;Inert atmosphere;

Steps:

1

Under nitrogen, 4-chlorophenol (3.10 g, 24.1 mmol) and potassium hydroxide (1.17 g, 20.9 mmol) were mixed in 100 ml of N-methylpyrrolidone, and the reaction mixture was heated to 120° C. and reacted for 1 hour.Then 1-bromo-4-fluoro-2-trifluoromethylbenzene (5.00 g, 20.6 mmol) was added, and the resulting mixture was stirred at 140°C for 5 hours.After the reaction, it was cooled to room temperature and extracted with dichloromethane. The organic layer was washed with 10% aqueous lithium chloride solution, then washed with 10% aqueous sodium hydroxide solution, dried over anhydrous sodium sulfate, filtered and distilled to obtain oil 1-bromo-4-(4-chlorophenoxy)-2-trifluoromethylbenzene 6.53g, purity 95.42%, yield 87.99%

References:

CN112079797,2020,A Location in patent:Paragraph 0015; 0042-0043