2-chloro-6-(5-isopropyl-2-methylphenyl)-4-((1R,3r,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine synthesis

2synthesis methods

Product Name:2-chloro-6-(5-isopropyl-2-methylphenyl)-4-((1R,3r,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
CAS Number:1421253-42-0
Molecular formula:C25H33ClN4O
Molecular Weight:441.01

Methanesulfonic acid, 1,1,1-trifluoro-, 2-methyl-5-(1-methylethyl)phenyl ester

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2-chloro-6-(5-isopropyl-2-methylphenyl)-4-((1R,3r,5S)-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

1421253-42-0
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: caesium carbonate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct / tetrahydrofuran / 2 h / 140 °C / Microwave irradiation
2: potassium trimethylsilonate / 1,4-dioxane / 24 h / 140 °C / Sealed tube
3: Vilsmeier reagent / 1,2-dichloro-ethane / 18 h / 40 °C

References:

WO2013/16197,2013,A1

499-75-2 Synthesis

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References