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4-(trifluoromethyl)bicyclo[2.2.2]octane-1-carboxylic acid synthesis
- Product Name:4-(trifluoromethyl)bicyclo[2.2.2]octane-1-carboxylic acid
- CAS Number:14234-09-4
- Molecular formula:C10H13F3O2
- Molecular Weight:222.2
![4-methoxybicyclo[2.2.2]octane-1-carboxylic acid](/CAS/20180629/GIF/773-34-2.gif)
773-34-2
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![4-(trifluoromethyl)bicyclo[2.2.2]octane-1-carboxylic acid](/CAS/20200331/GIF/14234-09-4.gif)
14234-09-4
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: 35 percent Spectr. / sulfur tetrafluoride / 48 h / 150 °C
2: 48 percent / iodotrimethylsilane / CH2Cl2 / 120 h / Ambient temperature
3: 1.) t-BuLi / 1.) pentane, Et2O, from -100 deg C to -80 deg C, 15 min, 2.) pentane, Et2O, -100 deg C
References:
Adcock, William;Kok, Gaik B. [Journal of Organic Chemistry,1985,vol. 50,# 7,p. 1079 - 1087]
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![4-(trifluoromethyl)bicyclo[2.2.2]octane-1-carboxylic acid](/CAS/20200331/GIF/14234-09-4.gif)
14234-09-4
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