3-Morpholinone, 4-(phenylmethyl)-5-(trifluoromethyl)-, (5R)- synthesis

2synthesis methods

Product Name:3-Morpholinone, 4-(phenylmethyl)-5-(trifluoromethyl)-, (5R)-
CAS Number:1430086-51-3
Molecular formula:C12H12F3NO2
Molecular Weight:259.22

2-Propanol, 1,1,1-trifluoro-3-[(phenylmethyl)amino]-, (2S)-

177965-07-0
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3-Morpholinone, 4-(phenylmethyl)-5-(trifluoromethyl)-, (5R)-

1430086-51-3
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: triethylamine; triphenylphosphine / tetrachloromethane; acetonitrile / 24 h
2: sulfuric acid / water / 24 h
3: triethylamine / dichloromethane / 48 h / Cooling with ice
4: potassium carbonate / methanol; water / 15 h / Reflux

References:

Shcherbatiuk, Andriy V.;Shyshlyk, Oleg S.;Yarmoliuk, Dmytro V.;Shishkin, Oleg V.;Shishkina, Svitlana V.;Starova, Viktoriia S.;Zaporozhets, Olga A.;Zozulya, Sergey;Moriev, Roman;Kravchuk, Olga;Manoilenko, Olga;Tolmachev, Andrey A.;Mykhailiuk, Pavel K. [Tetrahedron,2013,vol. 69,# 19,p. 3796 - 3804]

Aziridine, 1-(phenylmethyl)-2-(trifluoromethyl)-, (2R)-

198019-15-7
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1430086-51-3
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References