ChemicalBook CAS DataBase List 2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)-

2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- synthesis

1synthesis methods

Product Name:2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)-
CAS Number:1432051-63-2
Molecular formula:C17H17F3N2O2
Molecular Weight:338.33

15760-35-7 Synthesis

15760-35-7
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2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)-

1432051-63-2
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: sodium hexamethyldisilazane / toluene / 0.08 h / 5 °C
2: n-butyllithium / tetrahydrofuran / 0.08 h / -70 °C
3: tetrafluoroboric acid / water / 2.5 h / 50 °C
4: phenylsilane / toluene / 50 °C

References:

Voight, Eric A.;Daanen, Jerome F.;Schmidt, Robert G.;Gomtsyan, Arthur;Dart, Michael J.;Kym, Philip R. [Journal of Organic Chemistry,2016,vol. 81,# 23,p. 12060 - 12064]