ChemicalBook CAS DataBase List 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)

1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI) synthesis

13synthesis methods

Product Name:1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)
CAS Number:14377-63-0
Molecular formula:C13H15NO2
Molecular Weight:217.26

110-89-4
3 suppliers
$15.96/100ML

536-74-3 Synthesis

536-74-3
302 suppliers
$10.00/1g

1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)-
Piperidine, 1-(oxophenylacetyl)- (9CI)

14377-63-0
21 suppliers
$376.00/1g

Yield:14377-63-0 86%

Reaction Conditions:

with selenium(IV) oxide;sulfuric acid in 1,4-dioxane at 80;Reagent/catalyst;

Steps:

B: Standard reaction procedure terminal alkyne
General procedure: B: Standard reaction procedure terminal alkyne: SeO₂ (1.0 mmol) was added to a solutionof terminal alkyne (1.0 mmol) in dioxan (1 ml) followed by the addition of 10mol% of H₂SO₄ and amine (1.0 mmol). The reaction mixturewas then heated at 80^oC for 10-12 h and the product formation wasmonitored by TLC. After completion, reaction mixture was partioned with waterethyl acetate, extracted with ethyl acetate (3 x 50ml). The combined organiclayers were washed with brine solution, concentrated on rotary evaporator andpurified by column chromatography using ethyl acetate and hexane to affordcorresponding pure products. Spectral data:N,N-diethylbenzamide (3a): ¹H NMR (CDCl_3,400 MHz): δ_H 7.26-7.40 (m,5H), 3.54 (s, 2H), 3.25 (s, 2H), 1.25(s, 3H), 1.10 (s, 3H); ¹³CNMR (CDCl_3,100 MHz): δ_c 171.32, 137.33, 129.10, 128.41, 126.28, 42.29, 39.23,14.23, 12.93. ESIMS: m/z 178.12 [M+H]⁺, Yield 90%.

References:

Meena, Samdarshi;Singh, Rohit;Vishwakarma, Ram A.;Aga, Mushtaq A.;Jain, Shreyans K. [Tetrahedron Letters,2016,vol. 57,# 33,p. 3715 - 3717] Location in patent:supporting information

FullText

110-89-4
3 suppliers
$15.96/100ML

591-50-4 Synthesis