ChemicalBook CAS DataBase List 2-(1 Lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride

2-(1 Lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride synthesis

5synthesis methods

Product Name:2-(1 Lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride
CAS Number:143924-45-2
Molecular formula:C10H16Cl2N2
Molecular Weight:235.1534

79099-07-3 Synthesis

79099-07-3
543 suppliers
$5.00/5g

2-(1 Lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride

143924-45-2
30 suppliers
$165.00/250 mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: 68 percent / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
2.1: 64 percent / Pd(PPh₃)4 / tetrahydrofuran / 1.5 h / 60 °C
3.1: 99 percent / H₂ / Pd/C / 1.5 h / 20 °C / 3102.89 Torr
4.1: 99 percent / HCl gas / ethyl acetate / -78 - 20 °C

References:

Patel, Meena V.;Kolasa, Teodozyj;Mortell, Kathleen;Matulenko, Mark A.;Hakeem, Ahmed A.;Rohde, Jeffrey J.;Nelson, Sherry L.;Cowart, Marlon D.;Nakane, Masaki;Miller, Loan N.;Uchic, Marie E.;Terranova, Marc A.;El-Kouhen, Odile F.;Donnelly-Roberts, Diana L.;Namovic, Marian T.;Hollingsworth, Peter R.;Chang, Renjie;Martino, Brenda R.;Wetter, Jill M.;Marsh, Kennan C.;Martin, Ruth;Darbyshire, John F.;Gintant, Gary;Hsieh, Gin C.;Moreland, Robert B.;Sullivan, James P.;Brioni, Jorge D.;Stewart, Andrew O. [Journal of Medicinal Chemistry,2006,vol. 49,# 25,p. 7450 - 7465]

3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-carboxylic acid tert-butyl ester

206446-49-3
15 suppliers
$1012.00/1g

143924-45-2
30 suppliers
$165.00/250 mg

References

1-(tertbutoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yltrifluoromethanesulfonate

138647-49-1
121 suppliers
$25.00/1g

143924-45-2
30 suppliers
$165.00/250 mg

References

3',6'-DIHYDRO-2'H-[2,4']BIPYRIDINYL-1'-CARBOXYLIC ACID TERT-BUTYL ESTER

90606-77-2
8 suppliers
inquiry

143924-45-2
30 suppliers
$165.00/250 mg

References

581-47-5 Synthesis

581-47-5
128 suppliers
$16.00/1g

143924-45-2
30 suppliers
$165.00/250 mg

References