2-CHLORO-6-(4-METHOXYBENZYL)-6,7-DIHYDROPYRROLO[3,4-B]PYRIDIN-5-ONE synthesis
- Product Name:2-CHLORO-6-(4-METHOXYBENZYL)-6,7-DIHYDROPYRROLO[3,4-B]PYRIDIN-5-ONE
- CAS Number:1440519-73-2
- Molecular formula:C15H13ClN2O2
- Molecular Weight:288.73
1093879-99-2
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1440519-73-2
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Yield:1440519-73-2 55%
Reaction Conditions:
in tetrahydrofuran at 20; for 4 h;
Steps:
A.5 Step 5:
To a solution of (4-methoxyphenyl)methanamine (2.49 g, 18.15 mmol) in tetrahydrofuran (50 mL ) was added methyl 6-chloro-2-(chloromethyl)pyridine-3- carboxylate (4.0 g, 18.17 mmol). The mixture was stirred at room temperature for 4 h. The mixture was concentrated under vacuum. The residue was purified by flash column chromatography with 0-25% ethyl acetate in petroleum ether to afford 2-chloro-6-[(4- methoxyphenyl)methyl]-7H-pyrrolo[3,4-b]pyridin-5-one (2.90 g, 55%) as a yellow solid. MS m/z 289.0 [M+1]+.
References:
WO2022/20342,2022,A1 Location in patent:Page/Page column 40; 57
65719-09-7
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1440519-73-2
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1033809-42-5
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1440519-73-2
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177785-14-7
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1440519-73-2
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1093879-98-1
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1440519-73-2
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