ChemicalBook CAS DataBase List Pamiparib

Pamiparib synthesis

10synthesis methods

Product Name:Pamiparib
CAS Number:1446261-44-4
Molecular formula:C16H15FN4O
Molecular Weight:298.31

344-25-2 Synthesis

344-25-2
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1446261-44-4
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Yield:-

Steps:

Multi-step reaction with 12 steps
1.1: chloroform / 6 h / Reflux
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
2.2: 1.5 h / -78 °C / Inert atmosphere
3.1: thionyl chloride / methanol / 1 h / 0 °C
4.1: sodium carbonate / tetrahydrofuran / 0 - 20 °C
5.1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -78 °C / Inert atmosphere
6.1: potassium carbonate / methanol / 0 - 20 °C
7.1: N,N,N',N'-tetramethylguanidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere
8.1: zinc dibromide / toluene / 15 h / 80 °C
9.1: sodium tetrahydroborate / methanol / 4 h / Reflux; Inert atmosphere
10.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 20 °C
11.1: methanesulfonic acid / 1 h / 60 °C
12.1: acetic acid; hydrazine hydrate / methanol / 5 h / Reflux

References:

Wang, Hexiang;Ren, Bo;Liu, Ye;Jiang, Beibei;Guo, Yin;Wei, Min;Luo, Lusong;Kuang, Xianzhao;Qiu, Ming;Lv, Lei;Xu, Hong;Qi, Ruipeng;Yan, Huibin;Xu, Dexu;Wang, Zhiwei;Huo, Chang-Xin;Zhu, Yutong;Zhao, Yuan;Wu, Yiyuan;Qin, Zhen;Su, Dan;Tang, Tristin;Wang, Fan;Sun, Xuebing;Feng, Yingcai;Peng, Hao;Wang, Xing;Gao, Yajuan;Liu, Yong;Gong, Wenfeng;Yu, Fenglong;Liu, Xuesong;Wang, Lai;Zhou, Changyou [Journal of Medicinal Chemistry,2020,vol. 63,# 24,p. 15541 - 15563]

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1446261-61-5
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1446261-44-4
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References

1342063-52-8
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$24.00/250mg

1446261-44-4
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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1446261-44-4
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References

1000210-73-0
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1446261-44-4
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References