ChemicalBook CAS DataBase List 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester

1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester synthesis

10synthesis methods

Product Name:1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester
CAS Number:144690-33-5
Molecular formula:C45H44N6O3
Molecular Weight:716.87

124750-51-2 Synthesis

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

124750-51-2
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144689-93-0 Synthesis

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

144689-93-0
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1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester

144690-33-5
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Yield: 93.8%

Reaction Conditions:

Stage #1:N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole;ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate with potassium carbonate in butanone at 60; for 2 h;
Stage #2: with N,N-dimethyl acetamide in butanone at 45; for 4 h;

Steps:

1 Example 1: Preparation of Compound 3
Weigh 24.0 g of compound 1, 55.7 g of compound 2, And add 124g of potassium carbonate, Then 200 mL of butanone was added, Warmed to 60 ° C, Stir for two hours, Cool to 45 , The composite catalyst (a mixture of polyethylene glycol 400 and N, N-dimethylacetamide in a mass ratio of 5: 1) Continue stirring for 4 hours, TLC detection, Show two kinds of raw materials are not left. The reaction is over, filter, The filtrate was collected, concentrate, Get oil, A mixture of 50 mL of ethanol and water (2: 1 by volume) Stirring, A large number of solid precipitation, filter, Collect the solid, Washed with 50mL n-hexane beating, The target compound 67.3g, Yield 93.8% The HPLC purity was 99.3%.

References:

Disha Pharmaceutical Group Co., Ltd.;Zhang Zhaoxing;Zhang Hongqiang;Qin Litai;Li Wei;Li Zongwen;Xia Haijian CN103012382, 2016, B Location in patent:Paragraph 0015; 0026-0027

76-83-5 Synthesis