2-Bromo-phenyl-3-methyl -1-( 4-bromophenyl ) -3- methyl- 5- pyrazolone synthesis
- Product Name:2-Bromo-phenyl-3-methyl -1-( 4-bromophenyl ) -3- methyl- 5- pyrazolone
- CAS Number:14580-15-5
- Molecular formula:C10H9BrN2O
- Molecular Weight:253.1
Yield:14580-15-5 89%
Reaction Conditions:
with acetic acid at 100; for 1 h;
Steps:
2.2 Synthetic route and procedures of pyrazolin-5-ones 2:
General procedure: To a neat solution containing 1,3-ketoester (2.84 mmol) and hydrazines (2.84mmol) was added glacialacetic acid (0.05 mL). The reaction mixture was stirred at 100 oil-bath for 1h. After the reaction was completed, the solution was cooled down to room temperature and then diluted with Et2O (2 mL)and stirred vigorously for 2h. The resultant solid was filtrated off, washed with Et2O (1 mL), driedunder vacuum at 50 for 6h to give pure pyrazolones 2 as white to light yellow crystal or powder in70-97.7% yield
References:
Lai, Xiaoyan;Zha, Gaofeng;Liu, Wei;Xu, Yan;Sun, Panpan;Xia, Tao;Shen, Yongcun [Synlett,2016,vol. 27,# 13,art. no. ST-2016-W0139-L,p. 1983 - 1988] Location in patent:supporting information
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