1,3-DIETHYL-2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBALDEHYDE synthesis

3synthesis methods

Product Name:1,3-DIETHYL-2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBALDEHYDE
CAS Number:14624-85-2
Molecular formula:C12H14N2O2
Molecular Weight:218.25

23814-14-4 Synthesis

2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID

23814-14-4
71 suppliers
$119.00/250mg

1,3-DIETHYL-2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBALDEHYDE

14624-85-2
8 suppliers
$485.00/1g

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 50 percent / NaH / dimethylformamide
2: 79 percent / LiBH₄ / methanol; tetrahydrofuran / 18 h / Heating
3: 42 percent / TEMPO; NCS; Bu₄NCl / CH₂Cl₂ / 5.5 h / pH 8.6

References:

Dombroski, Mark A.;Letavic, Michael A.;McClure, Kim F.;Barberia, John T.;Carty, Thomas J.;Cortina, Santo R.;Csiki, Csilla;Dipesa, Alan J.;Elliott, Nancy C.;Gabel, Christopher A.;Jordan, Crystal K.;Labasi, Jeff M.;Martin, William H.;Peese, Kevin M.;Stock, Ingrid A.;Svensson, Linne;Sweeney, Francis J.;Yu, Chul H. [Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,# 4,p. 919 - 923]

619-05-6
289 suppliers
$19.00/25g

14624-85-2
8 suppliers
$485.00/1g

References

1H-Benzimidazole-5-carboxylic acid, 1,3-diethyl-2,3-dihydro-2-oxo-, ethyl ester

680188-97-0
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inquiry

14624-85-2
8 suppliers
$485.00/1g

References