ChemicalBook CAS DataBase List (R,S)-Z-3-AMINO-5-CYCLOHEXYL-2-OXO-1,4-BENZODIAZEPINE

(R,S)-Z-3-AMINO-5-CYCLOHEXYL-2-OXO-1,4-BENZODIAZEPINE synthesis

8synthesis methods

Product Name:(R,S)-Z-3-AMINO-5-CYCLOHEXYL-2-OXO-1,4-BENZODIAZEPINE
CAS Number:146373-94-6
Molecular formula:C23H25N3O3
Molecular Weight:391.46

Carbamic acid, N-[1-(1H-benzotriazol-1-yl)-2-[[2-(cyclohexylcarbonyl)phenyl]amino]-2-oxoethyl]-, phenylmethyl ester

951220-93-2
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(R,S)-Z-3-AMINO-5-CYCLOHEXYL-2-OXO-1,4-BENZODIAZEPINE

146373-94-6
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$160.00/250mg

Yield:146373-94-6 410 mg

Reaction Conditions:

Stage #1: [benzotriazol-1-yl-(2-cyclohexanecarbonyl-phenylcarbamoyl)-methyl]-carbamic acid benzyl esterwith ammonia in tetrahydrofuran;methanol; for 18 h;
Stage #2: with ammonium acetate;acetic acid at 20; for 18 h;

References:

Carter, Malcolm C.;Alber, Dagmar G.;Baxter, Robert C.;Bithell, Sian K.;Budworth, Jo;Chubb, Ann;Cockerill, G. Stuart;Dowdell, Verity C. L.;Henderson, Elisa A.;Keegan, Sally J.;Kelsey, Richard D.;Lockyer, Michael J.;Stables, Jeremy N.;Wilson, Lara J.;Powell, Kenneth L. [Journal of Medicinal Chemistry,2006,vol. 49,# 7,p. 2311 - 2319]

N-[2-(cyclohexylcarbonyl)phenyl]Acetamide

146373-93-5
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146373-94-6
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$160.00/250mg

References

525-76-8 Synthesis

525-76-8
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$60.39/10g

146373-94-6
15 suppliers
$160.00/250mg

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621-84-1 Synthesis

621-84-1
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$7.00/25g

146373-94-6
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$160.00/250mg

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3432-87-9
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146373-94-6
15 suppliers
$160.00/250mg

References