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146395-96-2

Benzeneacetonitrile, 3,4-dichloro-α-[3-[(tetrahydro-2H-pyran-2-yl)oxy]propyl]- synthesis

2synthesis methods
Benzeneacetonitrile, 3,4-dichloro-α-[3-[(tetrahydro-2H-pyran-2-yl)oxy]propyl]-

146395-96-2
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: p-TsOH / tetrahydrofuran
2: 82 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature

References:

Chen, Huai G.;Chung;Goel;Johnson;Kesten;Knobelsdorf;Lee;Rubin [Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,# 5,p. 555 - 560]