(2E)-1-(2,4-dichlorophenyl)-3-(4-ethoxyphenyl)prop-2-en-1-one synthesis

Yield:1486549-12-5 79%

Reaction Conditions:

with potassium hydroxide in ethanol; for 3 h;Reflux;Solvent;Temperature;Time;

Steps:

Method A.

General procedure: The 4% ethanolic solution of KOH (15 mL) was added to a stirred solution of 20,40-dichloro-acetophenone (0.5 g, 2.65 mmol, 1 eq) and aromatic aldehyde (2.65 mmol, 1 eq) in EtOH (25 mL) and resulting reaction mixture was refluxed for 3 h. The reaction was quenched with diluted aqueous. HCl, EtOH evaporated under a stream of N₂, and resulting reaction mixture was partitioned between H₂O (25 mL) and CH₂Cl₂ (350 mL). The organic extract was dried over anhydrous Na₂SO₄, filtered, and concentrated under reduced pressure to afford saturated solution that upon standing yielded crystals of enone (4a-e) in good yield (75-92%).

References:

Sultan, Aeysha;Raza, Abdul Rauf [Synthetic Communications,2014,vol. 44,# 3,p. 417 - 423]