8-aMino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid synthesis

6synthesis methods

Product Name:8-aMino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid
CAS Number:148703-26-8
Molecular formula:C9H8ClNO4
Molecular Weight:229.62

1,4-Benzodioxin-5-carboxylic acid, 8-(acetylamino)-2,3-dihydro-

66411-27-6
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8-aMino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid

148703-26-8
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Yield:148703-26-8 67.7%

Reaction Conditions:

with N-chloro-succinimide;acetic acid at 50 - 85; for 8 h;Industrial scale;

References:

Lienard, Philippe;Gradoz, Philippe;Greciet, Hélène;Jegham, Samir;Legroux, Didier [Organic Process Research and Development,2017,vol. 21,# 1,p. 18 - 22] Location in patent:supporting information

1,4-Benzodioxin-5-carboxylic acid, 8-(acetylamino)-7-chloro-2,3-dihydro-

152045-64-2
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148703-26-8
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References

66411-17-4 Synthesis

6,7-Dibromo-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid

66411-17-4
18 suppliers
$192.50/250mg

148703-26-8
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References

4442-53-9 Synthesis

2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid

4442-53-9
173 suppliers
$7.00/1g

148703-26-8
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66411-18-5 Synthesis

6,7-Dibromo-8-nitro-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid

66411-18-5
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148703-26-8
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References