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151541-15-0

Ethyl 3-(4-(benzyloxy)-3,5-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate synthesis

5synthesis methods
-

Yield:151541-15-0 41%

Reaction Conditions:

Stage #1: ethyl 2-(2-methoxyphenoxy)acetatewith lithium diisopropyl amide in tetrahydrofuran at -78; for 1.16667 h;Inert atmosphere;
Stage #2: 4-(benzyloxy)-3,5-dimethoxybenzaldehyde in tetrahydrofuran at -78; for 2 h;Inert atmosphere;

References:

Altmann, Lisa-Marie;Heinrich, Markus R.;Hofmann, Dagmar;Hofmann, Laura Elena;Prusko, Lea [Advanced synthesis and catalysis,2020] Location in patent:supporting information