ChemicalBook CAS DataBase List 7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER

7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER synthesis

10synthesis methods

Product Name:7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER
CAS Number:152628-00-7
Molecular formula:C13H16N2O2
Molecular Weight:232.28

152628-01-8 Synthesis

Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate

152628-01-8
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7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER

152628-00-7
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$269.00/250mg

Yield: 96.6%

Reaction Conditions:

with sodium dithionite in water at 70 - 100;Product distribution / selectivity;

Steps:

I.1
Example 1:4-butyramido-3-methyl-5-nitro methyl benzoate (II) (50 gm, 0.178 moles), was suspended in water (300 ml) and heated to 70-80 °C. A suspension of sodium dithionite (108.7 gm, 0.536 moles) in water (300 ml) was added gradually to the above mass and the temperature is raised to 90-100 °C. After the reaction completed, the pH of the reaction mixture was adjusted to 9-10 and extracted with ethyl acetate (3x200 ml) and the combined organic layer was concentrated under reduced pressure to give methyl-4-methyl-2-propyl-lH-benzimidazole-6- carboxylate (40 gms, Yield : 96.6 %) of formula IV.

References:

OGENE SYSTEMS (I) PVT LTD;LAKKOJU, Chakrapani;KONETI, Naga Raju;KOKKALLA, Sridhar;MALLELA, Sambhu Prasad Sarma;BOYAPATI, Nanoranjan Choudary WO2012/28925, 2012, A2 Location in patent:Page/Page column 11

67-56-1 Synthesis