![](/CAS/GIF/152628-00-7.gif)
7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER
- CAS Number:152628-00-7
- Molecular formula:C13H16N2O2
- Molecular Weight:232.28
![Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate](/CAS/GIF/152628-01-8.gif)
152628-01-8
171 suppliers
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![7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/152628-00-7.gif)
152628-00-7
84 suppliers
$269.00/250mg
Yield: 96.6%
Reaction Conditions:
with sodium dithionite in water at 70 - 100;Product distribution / selectivity;
Steps:
I.1
Example 1:4-butyramido-3-methyl-5-nitro methyl benzoate (II) (50 gm, 0.178 moles), was suspended in water (300 ml) and heated to 70-80 °C. A suspension of sodium dithionite (108.7 gm, 0.536 moles) in water (300 ml) was added gradually to the above mass and the temperature is raised to 90-100 °C. After the reaction completed, the pH of the reaction mixture was adjusted to 9-10 and extracted with ethyl acetate (3x200 ml) and the combined organic layer was concentrated under reduced pressure to give methyl-4-methyl-2-propyl-lH-benzimidazole-6- carboxylate (40 gms, Yield : 96.6 %) of formula IV.
References:
OGENE SYSTEMS (I) PVT LTD;LAKKOJU, Chakrapani;KONETI, Naga Raju;KOKKALLA, Sridhar;MALLELA, Sambhu Prasad Sarma;BOYAPATI, Nanoranjan Choudary WO2012/28925, 2012, A2 Location in patent:Page/Page column 11
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$7.29/5ml-f
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1000210-73-0
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![7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/152628-00-7.gif)
152628-00-7
84 suppliers
$269.00/250mg
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668276-43-5
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![Butyric Acid](/CAS/GIF/107-92-6.gif)
107-92-6
553 suppliers
$9.00/5g
![7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/152628-00-7.gif)
152628-00-7
84 suppliers
$269.00/250mg
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675882-71-0
73 suppliers
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![7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/152628-00-7.gif)
152628-00-7
84 suppliers
$269.00/250mg
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18595-14-7
294 suppliers
$8.00/5g
![7-METHYL-2-PROPYL-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/152628-00-7.gif)
152628-00-7
84 suppliers
$269.00/250mg