(R)-2-(5-bromo-4-methylthiazol-2-yl)propane-1,2-diol synthesis

3synthesis methods

Product Name:(R)-2-(5-bromo-4-methylthiazol-2-yl)propane-1,2-diol
CAS Number:1558007-98-9
Molecular formula:C7H10BrNO2S
Molecular Weight:252.13

124341-73-7 Synthesis

124341-73-7
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(R)-2-(5-bromo-4-methylthiazol-2-yl)propane-1,2-diol

1558007-98-9
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: N-Bromosuccinimide / 0 - 20 °C
2: acetic acid; sulfuric acid / 20 h / 80 - 85 °C
3: AD-mix-α / tert-butyl alcohol; water; tetrahydrofuran / 60 h / 20 - 25 °C

References:

Huang, Qinhua;Johnson, Ted W.;Bailey, Simon;Brooun, Alexei;Bunker, Kevin D.;Burke, Benjamin J.;Collins, Michael R.;Cook, Andrew S.;Cui, J. Jean;Dack, Kevin N.;Deal, Judith G.;Deng, Ya-Li;Dinh, Dac;Engstrom, Lars D.;He, Mingying;Hoffman, Jacqui;Hoffman, Robert L.;Johnson, Patrick S.;Kania, Robert S.;Lam, Hieu;Lam, Justine L.;Le, Phuong T.;Li, Qiuhua;Lingardo, Laura;Liu, Wei;Lu, Melissa West;McTigue, Michele;Palmer, Cynthia L.;Richardson, Paul F.;Sach, Neal W.;Shen, Hong;Smeal, Tod;Smith, Graham L.;Stewart, Albert E.;Timofeevski, Sergei;Tsaparikos, Konstantinos;Wang, Hui;Zhu, Huichun;Zhu, Jinjiang;Zou, Helen Y.;Edwards, Martin P. [Journal of Medicinal Chemistry,2014,vol. 57,# 4,p. 1170 - 1187]

5-bromo-4-methyl-2-(prop-1-en-2-yl)thiazole

1558007-96-7
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1558007-98-9
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References

2-(5-bromo-4-methylthiazol-2-yl)propan-2-ol

1346819-12-2
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1558007-98-9
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References