(S)-2-Hydroxy-pentanedioic Acid 5-(Phenylmethyl) Ester synthesis

5synthesis methods

Product Name:(S)-2-Hydroxy-pentanedioic Acid 5-(Phenylmethyl) Ester
CAS Number:156693-50-4
Molecular formula:C12H14O5
Molecular Weight:238.24

Pentanedioic acid, 2-hydroxy-, 1-(1,1-dimethylethyl) 5-(phenylmethyl) ester, (2S)-

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(S)-2-Hydroxy-pentanedioic Acid 5-(Phenylmethyl) Ester

156693-50-4
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Yield:-

Reaction Conditions:

with trifluoroacetic acid at 0; for 2 h;

Steps:

248.2

Cooled TFA (5 mL) was added to 1-tert-butyl (S)-5-benzyl 2-hydroxypentanedioate (347 mg, 1.18 mmol), and the mixture was stirred at 0°C for 2 hr. The reaction mixture was concentrated under reduced pressure, and the obtained residue was subjected twice to azeotropy with toluene to give crude (S)-5-(benzyloxy)-2-hydroxy-5-oxopentanoic acid as a colorless oil.

References:

TW2016/2105,2016,A Location in patent:Paragraph 1100