tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-b]pyridine-4(5H)-carboxylate synthesis

4synthesis methods

Product Name:tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-b]pyridine-4(5H)-carboxylate
CAS Number:1569514-57-3
Molecular formula:C11H17N3O2
Molecular Weight:223.27

24424-99-5 Synthesis

24424-99-5
821 suppliers
$13.50/25G

4,5,6,7-Tetrahydro-2H-pyrazolo[4,3-b]pyridine HCl

1187830-47-2
69 suppliers
$81.00/100mg

tert-butyl 6,7-dihydro-1H-pyrazolo[4,3-b]pyridine-4(5H)-carboxylate

1569514-57-3
26 suppliers
$250.00/0.5g

Yield:1569514-57-3 96%

Reaction Conditions:

with potassium carbonate in dichloromethane;water; for 15 h;

Steps:

5a.a

a) 4,5,6,7-Tetrahydro-2H-pyrazolo[4,3-b]pyridine.HCl (319 mg, 2 mmol) was combined with Boc₂O (480 mg, 2.2 mmol) and K₂CO₃(1.3 mL, 3 M aqueous, 2 equiv) in CH₂Cl₂(10 mL). After 15 hours, the starting amine was consumed (LCMS). The reaction slurry was washed with brine and the organic layer was dried on MgSO₄, filtered, and concentrated to give a viscous yellow oil (446 mg, 96%) that was used without further purification. MS: (ES) m/z calculated for C₁₁H₁₈N₃O₂[M+H]+ 224.1, found 224.2.