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(S)-1-tert-butyl 2-ethyl 4,4-dimethyl-5- oxopyrrolidine-1,2-dicarboxylate synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: DMAP / triethylamine; CH2Cl2
2.1: LiN(SiMe3)2 / tetrahydrofuran / 0.75 h / -78 °C
2.2: 11 percent / tetrahydrofuran / -78 °C

References:

Gu, Zi-Qiang;Li, Min [Tetrahedron Letters,2003,vol. 44,# 15,p. 3203 - 3205]