Methyl 2,3:4,5:6,7-tri-O-isopropylidene-D-glycero-D-gulo-heptonate synthesis
- Product Name:Methyl 2,3:4,5:6,7-tri-O-isopropylidene-D-glycero-D-gulo-heptonate
- CAS Number:1595285-44-1
- Molecular formula:C17H28O8
- Molecular Weight:360.4
67-56-1
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Yield:1595285-44-1 85%
Reaction Conditions:
with hydrogenchloride at 0; for 1 h;Reflux;Large scale;Temperature;
Steps:
4.1
10kg of soluble sodium glucoheptanoate 50L 2,2- dimethoxypropane and cooled to 0 deg.] C, under stirring, added dropwise to the system 25L of hydrochloric acid solution in methanol, the reaction was stirred at reflux for 1 hour after the addition was complete,And then cooled to 0 ° C. The pH was adjusted to 7 with sodium carbonate. The filtrate was filtered to obtain a filtrate. The resulting filtrate was distilled under reduced pressure. After removing the solvent, 50 L of petroleum ether was added thereto, followed by washing with 50 L of water,The resulting petroleum ether phase was distilled under reduced pressure to give Compound 1,Yield 90%;
References:
CN106397500,2017,A Location in patent:Paragraph 0022
13007-85-7
134 suppliers
$30.00/10g
77-76-9
387 suppliers
$9.00/5ml
1595285-44-1
3 suppliers
inquiry