16-(Benzyloxy)-16-Oxohexadecanoic Acid synthesis
- Product Name:16-(Benzyloxy)-16-Oxohexadecanoic Acid
- CAS Number:146004-98-0
- Molecular formula:C23H36O4
- Molecular Weight:376.53
505-54-4
339 suppliers
$5.00/100mg
100-39-0
434 suppliers
$10.00/10 g
146004-98-0
37 suppliers
$21.00/250mg
Yield: 55.6%
Reaction Conditions:
with sodium carbonate in 2-methyltetrahydrofuran;water at 75; for 22 h;
Steps:
1 Example 1
Add sodium carbonate (424mg, 4.0mmol) to the reaction flask And water (14.3g, 794.4mmol),Add after stirring and dissolvingHexadecanedioic acid (1.43 g, 5.0 mmol),2-methyltetrahydrofuran (35.0g) and benzyl bromide (1.37g, 8.0mmol),The reaction system is heated to 75 ° C.The reaction was stopped by stirring for 22 h.Add hydrochloric acid to the system to make the pH of the aqueous phase reach 1-3.The layers were separated and the organic layer was spin-dried to obtain a solid residue.The rotary residue was slurried with dichloromethane (28 g), filtered,The filtrate was spin-dried to give a solid residue.The rotary evaporation residue was recrystallized from isopropanol (3 g) to obtain 1046 mg of a white solid,The yield was 55.6%.
References:
Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Lai Jinqiang;Feng Yahui;Mai Jiancong;Zhong Zhentao;Wang Zhongqing;Luo Zhonghua;Huang Fangfang CN110551023, 2019, A Location in patent:Paragraph 0027-0028
505-54-4
339 suppliers
$5.00/100mg
100-44-7
645 suppliers
$13.50/250G
146004-98-0
37 suppliers
$21.00/250mg
505-54-4
339 suppliers
$5.00/100mg
104-57-4
253 suppliers
$6.00/25g
146004-98-0
37 suppliers
$21.00/250mg
505-54-4
339 suppliers
$5.00/100mg
146004-98-0
37 suppliers
$21.00/250mg