ChemicalBook CAS DataBase List 3-Quinolinecarboxylic acid, 2-cyclopropyl-4-(4-fluorophenyl)-

3-Quinolinecarboxylic acid, 2-cyclopropyl-4-(4-fluorophenyl)- synthesis

7synthesis methods

Product Name:3-Quinolinecarboxylic acid, 2-cyclopropyl-4-(4-fluorophenyl)-
CAS Number:160375-37-1
Molecular formula:C19H14FNO2
Molecular Weight:307.32

Ethyl 2-cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-carboxylate

148516-11-4
101 suppliers
$11.00/1g

3-Quinolinecarboxylic acid, 2-cyclopropyl-4-(4-fluorophenyl)-

160375-37-1
10 suppliers
inquiry

Yield:160375-37-1 98.3%

Reaction Conditions:

with potassium hydroxide in ethanol at 75;Reagent/catalyst;Solvent;Temperature;

Steps:

4 Example 4

In 100 ml in shan Jingping, compound II joins the type 1.0g (HPLC: 98.91%), 60 ml ethanol stirring to dissolve, then adding 2.5g potassium hydroxide, heating under stirring to 75 °C reaction, TLC in substantially complete control to reaction (reaction time 4-7h), the reaction liquid to room temperature, evaporation to dryness under reduced pressure (temperature is 40-45°C, vacuum degree is 0.075-0.08 MPa), by adding 100 ml water, dilute hydrochloric acid for pH adjustment to 5-6, then using 100 ml ethyl acetate four times of extraction, using 10 ml saturated salt water to wash the organic phase, and the organic phase with anhydrous sodium sulfate for drying, final concentration (temperature is 40-45°C, vacuum degree is 0.08-0.085 MPa) organic phase, to obtain white powder 0.9g, HPLC: 98.86%, yield 98.3%.

References:

CN103664774,2016,B Location in patent:Page/Page column 0039; 0040

765-43-5 Synthesis