![](/CAS/GIF/161491-24-3.gif)
1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate synthesis
- Product Name:1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
- CAS Number:161491-24-3
- Molecular formula:C12H19NO5
- Molecular Weight:257.28
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
823 suppliers
$13.50/25G
![METHYL 4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE](/CAS/GIF/71486-53-8.gif)
71486-53-8
143 suppliers
$6.00/1g
![1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate](/CAS/GIF/161491-24-3.gif)
161491-24-3
174 suppliers
$8.00/1g
Yield:161491-24-3 100%
Reaction Conditions:
with sodium carbonate in tetrahydrofuran;water at 0; for 1 h;
Steps:
15i.1
Methyl 4-oxopiperidine-3-carboxylate hydrochloride (10.0 g, 51.6 mmol, 1 eq.) was dissolved in water (60 mL) at room temperature then cooled to 0° C. Added sodium carbonate (6.02 g, 56.8 mmol, 1.05 eq.) followed by the dropwise addition of BOC anhydride (11.84 g, 51.6 mmol, 1 eq.) in THF (50 mL) via an addition funnel. Stirred at 0° C. for 1 hour. Worked up by extracting 3 times with diethyl ether (50 mL). The diethyl ether extracts were combined and rinsed once (50 mL) with brine. The diethyl ether layer was dried over sodium sulfate and stripped to give 1-tert-butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate (13.29 g) as an amber oil. Yield=100%. 1H NMR (400 MHz) (CDCl3) δ 4.02 (s, 2H); 3.77 (s, 3H); 3.59 (s, 2H); 2.37 (s, 2H); 1.47 (s, 9H).
References:
US2005/54627,2005,A1 Location in patent:Page/Page column 114
![N-(tert-Butoxycarbonyl)-4-piperidone](/CAS/GIF/79099-07-3.gif)
79099-07-3
543 suppliers
$5.00/5g
![Dimethyl carbonate](/CAS/GIF/616-38-6.gif)
616-38-6
659 suppliers
$5.00/5G
![1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate](/CAS/GIF/161491-24-3.gif)
161491-24-3
174 suppliers
$8.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
823 suppliers
$13.50/25G
![Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride](/CAS/20180808/GIF/3939-01-3.gif)
3939-01-3
132 suppliers
$5.00/1g
![1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate](/CAS/GIF/161491-24-3.gif)
161491-24-3
174 suppliers
$8.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
823 suppliers
$13.50/25G
![1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate](/CAS/GIF/161491-24-3.gif)
161491-24-3
174 suppliers
$8.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
823 suppliers
$13.50/25G
![4-OXO-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/108554-34-3.gif)
108554-34-3
53 suppliers
inquiry
![1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate](/CAS/GIF/161491-24-3.gif)
161491-24-3
174 suppliers
$8.00/1g