7-Benzofurancarboxylic acid, 5-fluoro-2,3-dihydro-, methyl ester synthesis

5synthesis methods

Product Name:7-Benzofurancarboxylic acid, 5-fluoro-2,3-dihydro-, methyl ester
CAS Number:1616110-68-9
Molecular formula:C10H9FO3
Molecular Weight:196.18

35700-40-4 Synthesis

35700-40-4
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7-Benzofurancarboxylic acid, 5-fluoro-2,3-dihydro-, methyl ester

1616110-68-9
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: sulfuric acid / 3 h / Reflux
2.1: trifluoroacetic acid; nitric acid / 3.5 h / 0 - 20 °C
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 20 °C / 3102.97 Torr
4.1: hydrogenchloride; tetrafluoroboric acid; sodium nitrite / water; tetrahydrofuran / -15 - 20 °C
4.2: 2 h / Reflux

References:

Patel, Maulik R.;Bhatt, Aaditya;Steffen, Jamin D.;Chergui, Adel;Murai, Junko;Pommier, Yves;Pascal, John M.;Trombetta, Louis D.;Fronczek, Frank R.;Talele, Tanaji T. [Journal of Medicinal Chemistry,2014,vol. 57,# 13,p. 5579 - 5601]

1616110-67-8 Synthesis

7-Benzofurancarboxylic acid, 5-amino-2,3-dihydro-, methyl ester

1616110-67-8
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1616110-68-9
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References

133844-95-8 Synthesis

methyl 2,3-dihydrobenzofuran-7-carboxylate

133844-95-8
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1616110-68-9
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References

496-16-2 Synthesis

496-16-2
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$7.00/5g

1616110-68-9
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References

7-Benzofurancarboxylic acid, 2,3-dihydro-5-nitro-, methyl ester

1616110-66-7
1 suppliers
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1616110-68-9
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References