tert-butyl 1,2,6-triazaspiro[2.5]oct-1-ene-6-carboxylate synthesis

Yield:1620483-21-7 93%

Reaction Conditions:

Stage #1: N-tert-butyloxycarbonylpiperidin-4-onewith tert-butylhypochlorite;ammonia in methanol;tert-butyl alcohol at 20; for 4 h;Microwave irradiation;
Stage #2: with tert-butylhypochlorite in methanol;tert-butyl alcohol at 20; for 0.5 h;Inert atmosphere;

References:

Ibert, Quentin;Cauwel, Madeleine;Glachet, Thomas;Tite, Tony;Le Nahenec-Martel, Patricia;Lohier, Jean-Fran?ois;Renard, Pierre-Yves;Franck, Xavier;Reboul, Vincent;Sabot, Cyrille [Advanced Synthesis and Catalysis,2021,vol. 363,# 18,p. 4390 - 4398] Location in patent:supporting information