(R)-4-benzyl 3-tert-butyl 1,2,3-oxathiazolidine-3,4-dicarboxylate 2,2-dioxide synthesis

Yield:-

Steps:

Multi-step reaction with 4 steps
1: potassium carbonate / water; 1,4-dioxane / 16 h / 20 °C
2: N,N-dimethyl-formamide / 16 h / 20 °C
3: thionyl chloride; pyridine / acetonitrile / 3.5 h / -42 °C / Inert atmosphere
4: sodium periodate; ruthenium(III) trichloride hydrate / water; acetonitrile / 4.25 h / 0 - 20 °C

References:

Denoel, Thibaut;Zervosen, Astrid;Gerards, Thomas;Lemaire, Christian;Joris, Bernard;Blanot, Didier;Luxen, Andre [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 17,p. 4621 - 4628]