![](/CAS/20180808/GIF/162090-86-0.gif)
N-[4-(acetylamino)phenyl]-3-chloro-1-benzothiophene-2-carboxamide synthesis
- Product Name:N-[4-(acetylamino)phenyl]-3-chloro-1-benzothiophene-2-carboxamide
- CAS Number:162090-86-0
- Molecular formula:C17H13ClN2O2S
- Molecular Weight:344.82
![3-CHLOROBENZO[B]THIOPHENE-2-CARBONYL CHLORIDE](/CAS/GIF/21815-91-8.gif)
21815-91-8
129 suppliers
$12.00/1mg
![4'-Aminoacetanilide](/CAS/GIF/122-80-5.gif)
122-80-5
257 suppliers
$40.00/25g
![N-[4-(acetylamino)phenyl]-3-chloro-1-benzothiophene-2-carboxamide](/CAS/20180808/GIF/162090-86-0.gif)
162090-86-0
5 suppliers
inquiry
Yield:162090-86-0 69%
Reaction Conditions:
with triethylamine in 1,2-dimethoxyethane;toluene; for 24 h;Reflux;
Steps:
General method for the synthesis of substituted 3-chlorobenzo[b]thiophene-2-carboxamides (2a-c) and3-chlorothieno[2,3-b]thiophene-2-carboxamides(17a-c)
General procedure: To a solution of 3-chlorobenzo[b]thiophene-2-carbonyl chloride 1 and 3-chlorothieno[2,3-b]thiophene-2-carbonyl chloride 16 in toluene was added dropwise asolution of corresponding amine in toluene or DMF, followed by the addition ofEt3N. After refluxing and cooling, the obtained solid was filteredoff, washed with diluted HCl and water, and recrystallized.
References:
Aleksi?, Maja;Berto?a, Branimir;Nhili, Raja;Depauw, Sabine;Martin-Kleiner, Irena;David-Cordonnier, Marie-Hélène;Tomi?, Sanja;Kralj, Marijeta;Karminski-Zamola, Grace [European Journal of Medicinal Chemistry,2014,vol. 71,p. 267 - 281] Location in patent:supporting information