Propanedioic acid, 2-amino-2-[2-(4-octylphenyl)ethyl]-, 1,3-diethyl ester synthesis

2synthesis methods

Product Name:Propanedioic acid, 2-amino-2-[2-(4-octylphenyl)ethyl]-, 1,3-diethyl ester
CAS Number:162358-62-5
Molecular formula:C23H37NO4
Molecular Weight:391.54

64-17-5 Synthesis

64-17-5
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2-Amino-2-ethylmalonic acid diethyl ester

24257-60-1
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133826-41-2
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Propanedioic acid, 2-amino-2-[2-(4-octylphenyl)ethyl]-, 1,3-diethyl ester

162358-62-5
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Yield:162358-62-5 54%

Reaction Conditions:

Stage #1: diethyl 2-amino-2-ethylmalonate;4-n-octyliodobenzenewith silver hexafluoroantimonate;2-hydroxy-3-pyridinecarboxaldehyde;palladium diacetate in acetic acid at 20 - 130; for 24.1667 h;Darkness;
Stage #2: ethanolwith thionyl chloride at 0 - 90; for 5 h;

References:

Lin, Hua;Wang, Chao;Bannister, Thomas D.;Kamenecka, Theodore M. [Chemistry - A European Journal,2018,vol. 24,# 38,p. 9535 - 9541] Location in patent:supporting information

102831-44-7
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$8.00/250mg

162358-62-5
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References

Propanedioic acid, 2-amino-2-[2-(4-octylphenyl)ethyl]-, 1,3-diethyl ester Related Search:

Propanoicacid,2-formyl-3-oxo-,ethylester