ChemicalBook CAS DataBase List 4-fluoro-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one(WXC02963)

4-fluoro-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one(WXC02963) synthesis

1synthesis methods

Product Name:4-fluoro-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one(WXC02963)
CAS Number:168163-93-7
Molecular formula:C17H16FNO3S
Molecular Weight:333.38

24310-36-9 Synthesis

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

24310-36-9
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4-fluoro-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one(WXC02963)

168163-93-7
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Yield:168163-93-7 78%

Reaction Conditions:

Stage #1: 1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-onewith lithium diisopropyl amide in tetrahydrofuran at -78; for 0.5 h;
Stage #2: with N-fluorobis(benzenesulfon)imide in tetrahydrofuran at 0; for 1 h;

References:

Shimada;Taniguchi;Matsuhisa;Sakamoto;Yatsu;Tanaka [Chemical and Pharmaceutical Bulletin,2000,vol. 48,# 11,p. 1644 - 1651]