ChemicalBook CAS DataBase List 6-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

6-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester synthesis

12synthesis methods

Product Name:6-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
CAS Number:16867-53-1
Molecular formula:C12H12N2O3
Molecular Weight:232.24

Propanedioic acid, 2-[[(6-methyl-2-pyridinyl)amino]methylene]-, 1,3-dimethyl ester

24362-47-8
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6-Methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

16867-53-1
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Yield:16867-53-1 70%

Reaction Conditions:

with trichlorophosphate at 150; for 3 h;Sealed tube;

Steps:

2.1.1. Synthesis of 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate derivatives (Compound 1-3)

General procedure: Corresponding malonate derivative (1 equivalent) and POCl 3 (8.2 ml, 87.7 mmoles) were heated in a sealed tube at 150 °C for about 3 hours. After cooling the excess of POCl 3 was removed by distillation under reduced pressure. To the resulting mixture dichloromethane (DCM) was added and washed several times with aqueous sodium hydroxide solution (10%) to remove the traces of POCl 3. The organic layers was extracted twice with the DCM and dried over Na 2 SO 4, then concentrated under reduced pressure to give crude compounds ( 1-3 ).

References:

Palaniswamy, Parimaladevi;Shaik, Althaf;Thiruvenkatam, Vijay [Journal of Molecular Structure,2021,vol. 1224]