![](/CAS/GIF/170491-63-1.gif)
2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:170491-63-1
- Molecular formula:C10H19NO3
- Molecular Weight:201.26
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
821 suppliers
$13.50/25G
![2-(Hydroxymethyl)pyrrolidine](/CAS/GIF/498-63-5.gif)
498-63-5
146 suppliers
$34.00/5g
![2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/170491-63-1.gif)
170491-63-1
152 suppliers
$8.00/250mg
Yield:170491-63-1 98%
Reaction Conditions:
in dichloromethane at 20; for 16 h;
Steps:
353.1 Step 1. Synthesis of tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
Step 1.
Synthesis of tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate
A solution of 2-pyrrolidinemethanol (0.300 g, 1.98 mmol) in CH2Cl2 (5.0 mL) and di-tert-butyl dicarbonate (0.650 g, 1.98 mmol) were used to carry out the reaction.
After the reaction was stirred at room temperature for 16 h and work-up, the residue was purified by Isco Combi-Flash Companion column chromatography (0-10% MeOH in CH2Cl2) to give tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (0.590 g, 98%).
1H NMR (CDCl3, 300 MHz) δ 4.78 (br d, 1H), 4.05-3.90 (br, 1H), 3.67-3.53 (m, 2H), 3.49-3.41 (m, 1H), 3.34-3.26 (m, 1H), 2.00 (dddd, 1H), 1.85-1.72 (m, 2H), 1.60-1.50 (m, 1H), 1.46 (s, 9H).
References:
National Health Research Institutes;Ueng, Shau-Hua;Yeh, Shiu-Hwa;Lin, Shu-Yu;Shih, Chuan US2017/253569, 2017, A1 Location in patent:Paragraph 0994-0995
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15761-39-4
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![2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/170491-63-1.gif)
170491-63-1
152 suppliers
$8.00/250mg
![Methyl 1-Boc-5-oxopyrrolidine-2-carboxylate](/CAS/20180702/GIF/861657-91-2.gif)
861657-91-2
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$91.67/1g
![2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/170491-63-1.gif)
170491-63-1
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$8.00/250mg
![2-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/StructureFile/ChemBookStructure6/GIF/CB7136317.gif)
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![2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/170491-63-1.gif)
170491-63-1
152 suppliers
$8.00/250mg
![BOC-L-Proline](/CAS/20180808/GIF/15761-39-4.gif)
15761-39-4
603 suppliers
$5.00/10g
![2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/170491-63-1.gif)
170491-63-1
152 suppliers
$8.00/250mg