ChemicalBook CAS DataBase List 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester synthesis

7synthesis methods

Product Name:1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester
CAS Number:170908-81-3
Molecular formula:C20H31N5O10
Molecular Weight:501.49

TRI-T-BUTYL 1 4 7 10-TETRAAZACYCLODODECA

122555-91-3
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1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester

170908-81-3
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 99 percent / potassium carbonate / acetonitrile / 12 h / 70 °C
2: 95 percent / aq.NaOH / dioxane / 4 h / 50 °C
3: 86 percent / HBTU / acetonitrile / 24 h / 20 °C
4: 92 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 20 °C

References:

Li, Cong;Winnard Jr., Paul T.;Takagi, Tomoyo;Artemov, Dmitri;Bhujwalla, Zaver M. [Journal of the American Chemical Society,2006,vol. 128,# 47,p. 15072 - 15073]

819869-77-7 Synthesis