![](/CAS/GIF/170959-40-7.gif)
4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione synthesis
- Product Name:4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione
- CAS Number:170959-40-7
- Molecular formula:C7H8N4OS
- Molecular Weight:196.23
![4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID](/CAS/GIF/2510-32-9.gif)
2510-32-9
162 suppliers
$8.00/100mg
![4-Methylthiosemicarbazide](/CAS/GIF/6610-29-3.gif)
6610-29-3
204 suppliers
$19.00/1g
![4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione](/CAS/GIF/170959-40-7.gif)
170959-40-7
13 suppliers
$352.00/250mg
Yield:170959-40-7 53%
Reaction Conditions:
Stage #1: 4-methyl-1,3-oxazole-5-carboxylic acid;4-methylthiosemicarbazidewith 2-propane phosphonic acid anhydride;N-ethyl-N,N-diisopropylamine in ethyl acetate;N,N-dimethyl-formamide at 0 - 20; for 6.33333 h;
Stage #2: with sodium hydroxide in water at 70; pH=11;
Stage #3: with hydrogenchloride in water; pH=5; for 8 h;Product distribution / selectivity;
Steps:
123(1B)
4-Methyl-1.S-oxazole-δ-carboxylic acid (prepared according to the method of Preparation 1A, 12.9 g) was dissolved in DMF (60 mL) and treated with 4-methyl-3-thiosemicarbazide (11.61 g). Then disopropylethylamine (DIPEA) (31.OmL) was added at 2O0C. Under ice bath cooling, T3P 50% w/w in ethyl acetate (90 mL) was added drop wise, maintaining the temperature below 150C over 20 minutes. The resulting mixture was then stirred at 2O0C for 6 hours. EPO
References:
WO2007/22980,2007,A1 Location in patent:Page/Page column 131; 132
![4-Methylthiosemicarbazide](/CAS/GIF/6610-29-3.gif)
6610-29-3
204 suppliers
$19.00/1g
![4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione](/CAS/GIF/170959-40-7.gif)
170959-40-7
13 suppliers
$352.00/250mg
![4-METHYLOXAZOLE-5-CARBONYL CHLORIDE](/CAS/GIF/62348-24-7.gif)
62348-24-7
26 suppliers
$110.00/50mg
![4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione](/CAS/GIF/170959-40-7.gif)
170959-40-7
13 suppliers
$352.00/250mg