1-benzylpiperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate synthesis
- Product Name:1-benzylpiperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate
- CAS Number:171723-80-1
- Molecular formula:C25H26N2O2
- Molecular Weight:386.49
4727-72-4
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Yield:171723-80-1 100%
Reaction Conditions:
Stage #1: 1-benzyl-4-hydroxypiperidine;[1,1'-biphenyl]-2-yl-isocyanate at 70; for 12 h;
Stage #2: with hydrogenchloride in ethanol;water at 50;
Stage #3: with Celite;ammonium formate;palladium 10% on activated carbon at 20 - 40; for 12.33 h;
Steps:
8
Preparation 8 biphenyl-2-ylcarbamic Acid Piperidin-4-yl Ester biphenyl-2-isocyanate (97.5 g, 521 mmol) and 4-hydroxy-1-benzylpiperidine (105 g, 549 mmol), both commercially-available from Aldrich, Milwaukee, Wis., were heated together at 70° C. for 12 h, during which time the formation of biphenyl-2-ylcarbamic acid 1-benzylpiperidin-4-yl ester was monitored by LCMS.
References:
US2004/167167,2004,A1 Location in patent:Page/Page column 33
947-84-2
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171723-80-1
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4727-72-4
325 suppliers
$29.60/5g
171723-80-1
16 suppliers
inquiry