BIS(1,1-DIMETHYLETHYL)(3-BROMOPROPYL) IMIDODICARBONATE synthesis
1synthesis methods
- Product Name:BIS(1,1-DIMETHYLETHYL)(3-BROMOPROPYL) IMIDODICARBONATE
- CAS Number:172846-33-2
- Molecular formula:C13H24BrNO4
- Molecular Weight:338.24
Yield:172846-33-2 79%
Reaction Conditions:
Stage #1: iminodicarboxylic acid di-tert-butyl esterwith caesium carbonate in N,N-dimethyl-formamide at 20; for 1 h;Inert atmosphere;
Stage #2: 1,3-dibromo-propane in N,N-dimethyl-formamide at 20; for 24 h;Inert atmosphere;
References:
Schaffner, Arnaud-Pierre;Sansilvestri-Morel, Patricia;Despaux, Nicole;Ruano, Elisabeth;Persigand, Thierry;Rupin, Alain;Mennecier, Philippe;Vallez, Marie-Odile;Raimbaud, Eric;Desos, Patrice;Gloanec, Philippe [Journal of Medicinal Chemistry,2021,vol. 64,# 7,p. 3897 - 3910] Location in patent:supporting information