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1H-Imidazole-5-carboxylic acid, 4-(1-ethyl-1-hydroxypropyl)-2-propyl-, ethyl ester synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 86 percent / HCl / Ambient temperature
2: 83 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C

References:

Yanagisawa, Hiroaki;Amemiya, Yoshiya;Kanazaki, Takuro;Shimoji, Yasuo;Fujimoto, Koichi;Kitahara, Yoshiko;Sada, Toshio;Mizuno, Makoto;Ikeda, Masahiro;Miyamoto, Shuichi;Furukawa, Youji;Koike, Hiroyuki [Journal of Medicinal Chemistry,1996,vol. 39,# 1,p. 323 - 338]