ChemicalBook CAS DataBase List 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene synthesis

14synthesis methods

Product Name:2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene
CAS Number:172900-69-5
Molecular formula:C17H27BrO3
Molecular Weight:359.3

4383-06-6 Synthesis

4383-06-6
130 suppliers
$6.00/5g

2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene

172900-69-5
79 suppliers
$33.00/250mg

Yield:-

Steps:

Multi-step reaction with 7 steps
1.1: potassium carbonate / acetonitrile / 10 h / 25 - 35 °C / Reflux
2.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 10 °C
3.1: toluene / 2 h / 85 - 90 °C
4.1: sodium hydroxide; water / ethanol / 72 h / Reflux
4.2: pH 1 - 1.2
4.3: 35 h / 155 °C
5.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C
5.2: pH 1 - 1.2
6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C
6.2: 5 °C
7.1: triphenylphosphine; N-Bromosuccinimide / dichloromethane / 4 h / 5 - 10 °C

References:

WATSON LABORATORIES, INC.;BHANU, Manjunath, Narayan;NAIK, Samir;THOMAS, Rejoy WO2012/78147, 2012, A1