4-Chloro-6,7,8,9-Tetrahydro-5H-Pyrimido[4,5-B]Indole synthesis

4synthesis methods

Product Name:4-Chloro-6,7,8,9-Tetrahydro-5H-Pyrimido[4,5-B]Indole
CAS Number:173458-87-2
Molecular formula:C10H10ClN3
Molecular Weight:207.66

82703-36-4 Synthesis

6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indol-4-ol

82703-36-4
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4-Chloro-6,7,8,9-Tetrahydro-5H-Pyrimido[4,5-B]Indole

173458-87-2
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Yield:173458-87-2 62%

Reaction Conditions:

with trichlorophosphate at 100; for 1 h;

Steps:

1a Example 1a 4- hloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole

Example 1a 4- hloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b]indole A mixture comprising 148 mg (782 μητιο) 6,7,8,9-tetrahydro-5H-pyrimido[4,5- b]indol-4-ol which was prepared according to intermediate example 1 b and 5.47 mL phosphorus oxychloride was heated at 100° C for 1 hour. The reagent was removed and the residue purified by chromatography to give 106.8 mg (62%) of the title compound.

References:

WO2013/174743,2013,A1 Location in patent:Page/Page column 74

5H-Pyrimido[4,5-b]indole, 4-chloro-6,7,8,9-tetrahydro-9-(phenylmethyl)-

173458-81-6
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173458-87-2
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References

1H-Indole-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-1-(phenylmethyl)-

61479-14-9
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173458-87-2
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References

108-94-1 Synthesis

108-94-1
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173458-87-2
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References