1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile synthesis
- Product Name:1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile
- CAS Number:173859-39-7
- Molecular formula:C11H8F3NO
- Molecular Weight:227.18
Yield:173859-39-7 100%
Reaction Conditions:
with benzyl-triethyl-ammonium chloride;sodium hydroxide in lithium hydroxide monohydrate at 50;
References:
Huang, Adrian;Moretto, Alessandro;Janz, Kristin;Lowe, Michael;Bedard, Patricia W.;Tam, Steve;Di, Li;Clerin, Valerie;Sushkova, Natalia;Tchernychev, Boris;Tsao, Desiree H. H.;Keith Jr., James C.;Shaw, Gray D.;Schaub, Robert G.;Wang, Qin;Kaila, Neelu [Journal of Medicinal Chemistry,2010,vol. 53,# 16,p. 6003 - 6017] Location in patent:supporting information; experimental part
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