diethyl [[3,4-(methylenedioxy)anilino]methylene]malonate synthesis
- Product Name:diethyl [[3,4-(methylenedioxy)anilino]methylene]malonate
- CAS Number:17394-77-3
- Molecular formula:C15H17NO6
- Molecular Weight:307.3
Yield: 100%
Reaction Conditions:
in ethanol at 90; for 18 h;
Steps:
4.2.2 General procedure for synthesis of 16-27
General procedure: A solution of corresponding aniline (9.32mmol) and diethyl ethoxymethylenemalonate (9.32mmol) in ethanol (20mL) was heated at 90°C for 18h. After the solvent was removed under reduced pressure, the residue was extracted with ethyl acetate and water. The organic layer was washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by open column chromatography (eluent: n-hexane/ethyl acetate=4 : 1) to give corresponding compound 16-27.
References:
Mori, Shuichi;Iinuma, Hiroto;Manaka, Noriaki;Ishigami-Yuasa, Mari;Murayama, Takashi;Nishijima, Yoshiaki;Sakurai, Akiko;Arai, Ryota;Kurebayashi, Nagomi;Sakurai, Takashi;Kagechika, Hiroyuki [European Journal of Medicinal Chemistry,2019,vol. 179,p. 837 - 848]
105-53-3
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