ChemicalBook CAS DataBase List 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE

3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE synthesis

2synthesis methods

Product Name:3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE
CAS Number:175277-50-6
Molecular formula:C7H3ClF3NO
Molecular Weight:209.55

[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methanol

1033463-31-8
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3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE

175277-50-6
85 suppliers
$46.00/100mg

Yield: 57%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 0 - 23; for 3 h;

Steps:

3 Step 3: (3-chloro-5-(trifluoromethyl)pyridin-2-yl)methanol
DMP (60.2g, 142.lommol) was added portion wise to a stirred solution of(3-chloro-5-(trifluoromethyl)- pyridin-2-yl)methanol (15g, 71.Ommol) in DCM (lOOmL) at 0°C and stirred for 3 h at RT. The RM was filtered through a celite bed and washed with DCM (3x1 OOmL).The clear filtrate was washed with aq. NaHCO3 (200mL), water (200mL), brine(250mL), dried over anhydr. Na2SO4, filtered, concentrated under reduced pressure to get the crude product. The crude was purified by CC (0-5% EtOAc in PE) to give (3-chloro-5-(trifluoromethyl)pyridin-2-yl)methanol (8g, 57%) as liquid..

References:

GRÜNENTHAL GMBH;SCHUNK, Stefan;REICH, Melanie;JAKOB, Florian;DAMANN, Nils;HAURAND, Michael;KLESS, Achim;ROGERS, Marc;SUTTON, Kathy WO2015/158427, 2015, A1 Location in patent:Page/Page column 87

2,3-Dichloro-5-(trifluoromethyl)pyridine

69045-84-7
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$10.00/5g

175277-50-6
85 suppliers
$46.00/100mg

References

3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXALDEHYDE Related Search:

3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID 3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINECARBOXAMIDE