4-((tert-Butyldimethylsilyl)oxy)-2-fluorobenzaldehyde synthesis
1synthesis methods
- Product Name:4-((tert-Butyldimethylsilyl)oxy)-2-fluorobenzaldehyde
- CAS Number:175968-16-8
- Molecular formula:C13H19FO2Si
- Molecular Weight:254.37
Yield:175968-16-8 81%
Reaction Conditions:
Stage #1: 2-fluoro-4-hydroxybenzaldehydewith 1H-imidazole in N,N-dimethyl-formamide at 0; for 0.333333 h;Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride in N,N-dimethyl-formamide at 0 - 23;Inert atmosphere;
References:
Hewage, Achala N. D. Punchi;Yao, Huili;Nammalwar, Baskar;Gnanasekaran, Krishna Kumar;Lovell, Scott;Bunce, Richard A.;Eshelman, Kate;Phaniraj, Sahishna M.;Lee, Molly M.;Peterson, Blake R.;Battaile, Kevin P.;Reitz, Allen B.;Rivera, Mario [Journal of the American Chemical Society,2020,vol. 141,# 20,p. 8171 - 8184] Location in patent:supporting information