Ethyl 3-Methylpiperidine-3-carboxylate hydrochloride synthesis

Yield:176523-95-8 97%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 20; for 3 h;

Steps:

b h) Ethyl 3-rn ethylpi pen dine-3 -carboxyl ate

To a solution of 50 ml of 2.5 M hydrochloric acid in ethyl acetate 24.2 g (84.8 rnmol) of Iferf-butyi 3-ethyl 3-methyipiperidine-i,3-dicarboxyiate was added. The reaction mixture was stirred for 3 h at 20 °C, then 100 rnL of diethyl ether was added. The precipitated crystals werefiltered off, washed with diethyl ether to yield 16.28 g (97 %) of the title compound.

References:

WO2018/167630,2018,A1 Location in patent:Page/Page column 29